Estrumate

Composition
A clear colourless sterile aqueous solution for injection. Each ml of Estrumate contains 0.250 mg Cloprostenol.

Indications
As a synthetic prostaglandin analogue structurally related to Prostaglandin F₂ α (PGF ₂ α), for use in cattle and horses. Estrumate is a potent luteolytic agent. It causes functional and morphological regression of the corpus luteum (luteolysis) in cattle and horses followed by return to oestrus and normal ovulation. The recommended use in each target species is as follows:
Cattle: Suboestrus(or non detected oestrus- NDO), induction of parturition, termination of normal pregnancy, termination of abnormal pregnancy, chronic endometritis (Pyometra), ovarian luteal cysts, controlled breeding in cattle.
Horses: Induction of luteolysis following early foetal death and resorption, termination of persistent dioestrus, termination of psuedopregnancy, treatment of lactation anoestrus, establishing oestrus cycles in barren/maiden mares, as an aid to stud management.

Contra-indications
Do not administer to pregnant animals unless the objective is to terminate the pregnancy.

Side-effects
In horses, slight sweating and muscle tremors may occur after treatment. This appears to be transient and resolves without any treatment. In some cases, soft faeces may be passed shortly after treatment. Other possible reactions are increased heart and respiratory rate, abdominal discomfort, locomotor incoordination and lying down.
Localised post-injection bacterial infections, which may become generalised, are occasionally reported.

Dosage and administration
Cattle: 2.0 ml.
Ponies: 0.5 to 1.0 ml.
Thoroughbreds, hunters and heavy horses: 1.0 to 2.0 ml.
Administer by intramuscular injection observing normal aseptic precautions.
It is recommended that the vial is not broached more than 10 times and that the appropriate vial size should be used for prevailing usage conditions.